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Article

Intestinal injury and gut permeability in sickle cell disease

30 May 2019

Abstract excerpt

BACKGROUND: Due to recurrent hypoxia-reperfusion injury induced by vaso-occlusive crises (VOC), patients with sickle cell disease (SCD) may have intestinal injury and increased permeability. These may explain the qualitative and quantitative neutrophil abnormalities observed in these patients. METHODS: Serum intestinal fatty-acid binding protein (iFABP), lipopolysaccharides (LPS), and CD62L were measured by...

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PMID: 31146745
DOI: 10.1186/s12967-019-1938-8

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