Article

Bacterial and viral gut microbiome alterations characterize microbiome-immune-pathophysiology axes in sickle cell disease

2026-04-15

Abstract excerpt

Sickle cell disease (SCD) is a chronic, inherited condition rising across the globe. Prior studies revealed a direct link between the gut microbiome and disease micropathology via aged-like (ANs) neutrophils in mouse models. In SCD patients community-level shifts in the gut microbiome included decreases in diversity and the Firmicutes/Bacteroidetes (F:B) ratio, coupled to a loss of short chain fatty acid producing...

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Literature Corpus work: 20aab3fe-3b1b-5438-8e24-3d2dc424214b
DOI: 10.64898/2026.04.13.718288

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