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A Link Between Plasma Microbial Translocation, Microbiome, and Autoantibody Development in First‐Degree Relatives of Systemic Lupus Erythematosus Patients

20 May 2019

Abstract excerpt

Objective Systemic lupus erythematosus (SLE) is characterized by the production of antibodies against self antigens. However, the events underlying autoantibody formation in SLE remain unclear. This study was undertaken to investigate the role of plasma autoantibody levels, microbial translocation, and the microbiome in SLE. Methods Plasma samples from 2 cohorts, one with 18 unrelated healthy controls and 18...

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PMID: 31106972
DOI: 10.1002/art.40935

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