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Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases

18 May 2019

Abstract excerpt

BACKGROUND: The majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation. The results of preclinical studies demonstrated that metformin, a biguanide used to treat type 2 diabetes, rescues multiple phenotypes of FXS in both Drosophila and mouse models. Preliminary studies of...

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PMID: 31104364
DOI: 10.1002/mgg3.745

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