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Metformin: Do we finally have an anti-aging drug?

24 Oct 2013

Abstract excerpt

Studies in mammals have demonstrated that hyperglycemia and hyperinsulinemia are important factors in aging and cancer. Inactivation of insulin/insulin-like signaling increases lifespan in nematodes, fruit flies, and mice. Life-prolonging effects of caloric restriction are in part due to reduction in IGF-1, insulin, and glucose levels. Antidiabetic biguanides such as metformin, which reduce hyperglycemia and...

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PMID: 24189526
DOI: 10.4161/cc.26928

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