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Article

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Nature chemical biology - 1 Apr 2008

Chang Shuang, Bray Steven M, Li Zigang, Zarnescu Daniela C, He Chuan, Jin Peng, Warren Stephen T

Abstract excerpt

Fragile X syndrome is caused by the functional loss of the fragile X mental retardation 1 (FMR1) gene. Deletion of the FMR1 ortholog in Drosophila melanogaster (Fmr1) recapitulates many phenotypes associated with fragile X syndrome. We have discovered that Fmr1 mutant Drosophila die during development when reared on food containing increased levels of glutamate, which is consistent with the theory that FMR1 loss...

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Source

Identifiers

PMID: 18327252
DOI: 10.1038/nchembio.78

Genes

FMR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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