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Pathway-based classification of cancer subtypes

3 Jul 2012

Abstract excerpt

BACKGROUND: Molecular markers based on gene expression profiles have been used in experimental and clinical settings to distinguish cancerous tumors in stage, grade, survival time, metastasis, and drug sensitivity. However, most significant gene markers are unstable (not reproducible) among data sets. We introduce a standardized method for representing cancer markers as 2-level hierarchical feature vectors, with...

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PMID: 22759382
DOI: 10.1186/1745-6150-7-21

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