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Article

Replicase 1a gene plays a critical role in pathogenesis of avian coronavirus infectious bronchitis virus.

Virology - 1 Nov 2020

Zhao Jing, Zhang Keran, Cheng Jinlong, Jia Wenfeng, Zhao Ye, Zhang Guozhong

Abstract excerpt

Avian coronavirus infectious bronchitis virus (IBV) is an important pathogen threatening poultry production worldwide. Here, two recombinant IBVs (rYN-1a-aYN and rYN-1b-aYN) were generated in which ORF1a or ORF1b of the virulent YN genome were replaced by the corresponding regions from the attenuated strain aYN. The pathogenicity and virulence of rIBVs were evaluated in ovo and in vivo. The results revealed that...

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Identifiers

PMID: 32853833
DOI: 10.1016/j.virol.2020.08.009
PMCID: PMC7440038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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