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Article

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

2 May 2019

Abstract excerpt

Polyglutamine (polyQ) tracts are regions of low sequence complexity frequently found in transcription factors. Tract length often correlates with transcriptional activity and expansion beyond specific thresholds in certain human proteins is the cause of polyQ disorders. To study the structural basis of the association between tract length, transcriptional activity and disease, we addressed how the conformation of...

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PMID: 31048691
DOI: 10.1038/s41467-019-09923-2

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