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Removal of a Subset of Non-essential Genes Fully Attenuates a Highly Virulent Mycoplasma Strain

3 Apr 2019

Abstract excerpt

Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essential genes encoding, among others, potential virulence traits. Five genomic regions, representing approximately ten...

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PMID: 31001234
DOI: 10.3389/fmicb.2019.00664

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