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Dissemination of multiple carbapenem resistance genes in an in vitro gut model simulating the human colon

10 Mar 2019

Abstract excerpt

BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) pose a major global health risk. Mobile genetic elements account for much of the increasing CPE burden. OBJECTIVES: To investigate CPE colonization and the impact of antibiotic exposure on subsequent resistance gene dissemination within the gut microbiota using a model to simulate the human colon. METHODS: Gut models seeded with CPE-negative human...

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PMID: 30989197
DOI: 10.1093/jac/dkz106

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