Discovery of four novel furanosteroids and a new 4-methylprogesteroid from demethoxyviridin pathway-disrupted mutants of Nodulisporium sp. through cultivation time extension.

Abstract excerpt

Furanosteroids are a structurally distinctive class of fungal metabolites with significant biological activities, particularly well-known as potent phosphatidylinositol 3-kinase inhibitors. Previously, we have elucidated the biosynthetic pathway of demethoxyviridin, one of the most representative furanosteroids. Inspired by our previous finding that some non-specific tailoring enzymes in Nodulisporium sp....

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• Furans
• Molecular Structure
• Mutation
• Steroids
• Time Factors