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Article

Targeting the Spleen as an Alternative Site for Hematopoiesis

10 Apr 2019

Abstract excerpt

Bone marrow is the main site for hematopoiesis in adults. It acts as a niche for hematopoietic stem cells (HSCs) and contains non-hematopoietic cells that contribute to stem cell dormancy, quiescence, self-renewal, and differentiation. HSC also exist in resting spleen of several species, although their contribution to hematopoiesis under steady-state conditions is unknown. The spleen can however undergo...

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PMID: 30970171
DOI: 10.1002/bies.201800234

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