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Article

Significance of the Tks4 scaffold protein in bone tissue homeostasis

8 Apr 2019

Abstract excerpt

The main driver of osteoporosis is an imbalance between bone resorption and formation. The pathogenesis of osteoporosis has also been connected to genetic alterations in key osteogenic factors and dysfunction of bone marrow mesenchymal stem/stromal cells (BM-MSCs). Tks4 (encoded by the Sh3pxd2b gene) is a scaffold protein involved in podosome organization. Homozygous mutational inactivation of Sh3pxd2b causes...

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PMID: 30962481
DOI: 10.1038/s41598-019-42250-6

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