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Article

Interferon-Stimulated Genes—Mediators of the Innate Immune Response during Canine Distemper Virus Infection

1 Apr 2019

Abstract excerpt

The demyelinating canine distemper virus (CDV)-leukoencephalitis represents a translational animal model for multiple sclerosis. The present study investigated the expression of type I interferon (IFN-I) pathway members in CDV-induced cerebellar lesions to gain an insight into their role in lesion development. Gene expression of 110 manually selected genes in acute, subacute and chronic lesions was analyzed using...

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PMID: 30939763
DOI: 10.3390/ijms20071620

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