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Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

21 Mar 2019

Abstract excerpt

Synaptic damage precedes neuron death in Alzheimer’s disease (AD). Neurexins, NRXN1 , NRXN2, and NRXN3 , are presynaptic adhesion molecules that specify neuron synapses and regulate neurotransmitter release. Neurexins and postsynaptic neuroligins interact with amyloid beta oligomer (AβO) deposits in damaged synapses. NRXN3 gene variants have been associated with autism, addiction, and schizophrenia, however, not...

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PMID: 30902061
DOI: 10.1186/s13195-019-0475-2

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