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Article

Transcript diversity of Machado-Joseph disease gene (ATXN3) is not directly determined by SNPs in exonic or flanking intronic regions.

Journal of molecular neuroscience : MN - 1 Mar 2013

Bettencourt Conceição, Raposo Mafalda, Ros Raquel, Montiel Rafael, Bruges-Armas Jácome, Lima Manuela

Abstract excerpt

Alternative splicing (AS) of pre-mRNA is an important regulatory mechanism that enables one gene to produce multiple mature transcripts and, therefore, multiple protein isoforms. Besides the information content of core splicing signals, additional cis-regulatory elements (splicing enhancers and silencers) are needed to precisely define exons. AS is well documented in ATXN3 gene, which encodes for ataxin-3 and,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22706685
DOI: 10.1007/s12031-012-9832-3

Genes

ATXN3

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Transcript diversity of Machado-Joseph disease gene (ATXN3) is not directly determined by SNPs in exonic or flanking intronic regions.PMID 22706685Read ↗

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