Article
Epitope mapping of histo blood group antigens bound to norovirus VLPs using STD NMR experiments reveals fine details of molecular recognition.
Glycoconjugate journal - 1 Oct 2017
Fiege Brigitte, Leuthold Mila, Parra Francisco, Dalton Kevin P, Meloncelli Peter J, Lowary Todd L, Peters Thomas
Abstract excerpt
Attachment of human noroviruses to histo blood group antigens (HBGAs) is thought to be critical for the infection process. Therefore, we have determined binding epitopes of synthetic type 1 to 6 blood group A- and B-tetrasaccharides binding to GII.4 human Norovirus virus like particles (VLPs) using STD NMR experiments. So far, little information is available from crystal structure analysis studies on the...
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