Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density

20 Mar 2019

Abstract excerpt

Abstract The corneal endothelium is vital for transparency and proper hydration of the cornea. Here, we conduct a genome-wide association study of corneal endothelial cell density (cells/mm2), coefficient of cell size variation (CV), percentage of hexagonal cells (HEX) and central corneal thickness (CCT) in 6,125 Icelanders and find associations at 10 loci, including 7 novel. We assess the effects of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal surgery and disorders
Share to Glaucoma and retinal disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30894546
DOI: 10.1038/s41467-019-09304-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell densityPMID 30894546Read ↗

Genetic Variants Associated With Corneal Biomechanical Properties and Potentially Conferring Susceptibility to Keratoconus in a Genome-Wide Association StudySemantic proximity Read ↗

Genome-wide association study of corneal biomechanical properties identifies over 200 loci providing insight into the genetic etiology of ocular diseases.Semantic proximity Read ↗

A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness.Semantic proximity Read ↗

Genetic and Demographic Determinants of Fuchs Endothelial Corneal Dystrophy Risk and SeveritySemantic proximity Read ↗

Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants.Semantic proximity Read ↗

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.Semantic proximity Read ↗

A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus.Semantic proximity Read ↗

Association analysis of exome variants and refraction, axial length, and corneal curvature in a European-American population.Semantic proximity Read ↗

Genome-wide discovery reveals 30 loci for choroidal thickness and uncovers potential causal links with angle-closure glaucomaSemantic proximity Read ↗

The +57C>T substitution in microRNA-184 is associated with microphthalmia, retinal detachment, and altered ocular developmentSemantic proximity Read ↗

Heterogeneity of human corneal endothelium implicates lncRNA NEAT1 in Fuchs endothelial corneal dystrophySemantic proximity Read ↗

Association of shared gene polymorphisms for refraction and axial length with corneal biomechanical properties in children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.