Article

Cell line-dependent effects of spheroid formation method on drug response in melanoma models

2026-05-14

Abstract excerpt

In this study, we evaluated the impact of different in vitro 3D culture modelling methods on the activity of doxorubicin (DOX) and 5-fluorouracil (5-FU) in human melanoma spheroids. Human melanoma A375 and IGR39 spheroids were generated using the hanging drop and non-adhesive surface methods. Spheroid growth dynamics were assessed by measuring changes in spheroid diameter. To compare the effects of anticancer drug...

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Literature Corpus work: 93141d16-cd38-50bb-9cd7-f6b8af6c2f5d
DOI: 10.64898/2026.05.12.724514

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