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Development and validation of a TP53-associated immune prognostic model for hepatocellular carcinoma

16 Mar 2019

Abstract excerpt

BACKGROUND: TP53 mutation is the most common mutation in hepatocellular carcinoma (HCC), and it affects the progression and prognosis of HCC. We investigated how TP53 mutation regulates the HCC immunophenotype and thus affects the prognosis of HCC. METHODS: HCC samples. Then, the influence of the IPM on the immune microenvironment in HCC was comprehensively analysed. FINDINGS: TP53 mutation resulted in the...

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PMID: 30885723
DOI: 10.1016/j.ebiom.2019.03.022

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