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Understanding the Amyloid Hypothesis in Alzheimer’s Disease

12 Mar 2019

Abstract excerpt

The amyloid hypothesis (AH) is still the most accepted model to explain the pathogenesis of inherited Alzheimer's disease (IAD). However, despite the neuropathological overlapping with the non-inherited form (NIAD), AH waver in explaining NIAD. Thus, 30 years after its first statement several questions are still open, mainly regarding the role of amyloid plaques (AP) and apolipoprotein E (APOE). Accordingly, a...

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PMID: 30883346
DOI: 10.3233/jad-180802

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