Article
RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF.
RNA biology - 1 Sept 2016
Tsuchiya Motohiro, Kalurupalle Swathi, Kumar Parameet, Ghoshal Sarani, Zhang Yongqing, Lehrmann Elin, Becker Kevin G, Gorospe Myriam, Biswas Roopa
Abstract excerpt
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the most frequent of which is F508del-CFTR. CF is characterized by excessive secretion of pro-inflammatory mediators into the airway lumen, inducing a highly inflammatory cellular phenotype. This process triggers fibrosis, causing airway destruction and leading to...
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