Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy

1 Jan 2019

Abstract excerpt

The interplay between p53 and RAS signaling regulates cancer chemoresistance, but the detailed mechanism is unclear. In this study, we investigated the interactive effects of p53 and RAS on ovarian cancer cisplatin resistance to explore the potential therapeutic targets. Methods: An inducible p53 and RAS mutants active in either MAPK/ERK (S35 and E38) or PI3K/AKT (C40) or both (V12) were sequentially introduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30867818
DOI: 10.7150/thno.29673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagyPMID 30867818Read ↗

Regulation of autophagy and EMT by the interplay between p53 and RAS during cancer progression (Review)Semantic proximity Read ↗

Triangular Relationship between p53, Autophagy, and Chemotherapy ResistanceSemantic proximity Read ↗

Mutant p53 improves cancer cells’ resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6Semantic proximity Read ↗

RASA4 inhibits the HIFα signaling pathway to suppress proliferation of cervical cancer cellsSemantic proximity Read ↗

p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell DeathSemantic proximity Read ↗

SHCBP1 promotes cisplatin resistance of ovarian cancer through AKT/mTOR/Autophagy pathwaySemantic proximity Read ↗

SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell linesSemantic proximity Read ↗

The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development.Semantic proximity Read ↗

SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis.Semantic proximity Read ↗

P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9.Semantic proximity Read ↗

Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancerSemantic proximity Read ↗

The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.