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Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos

27 Feb 2019

Abstract excerpt

STUDY QUESTION: Does the oxygen concentration in the culture medium [either physiologic (5%) or atmospheric (20%)] affect mitochondrial ultrastructure and function in preimplantation mouse embryos generated by IVF? SUMMARY ANSWER: Embryos cultured in 20% oxygen show increased mitochondrial abnormalities compared to embryos cultured in 5% oxygen. WHAT IS KNOWN ALREADY: ART are widely used and have resulted in the...

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PMID: 30865267
DOI: 10.1093/humrep/dez011

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