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Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes betweenin vivoandin vitrofertilized early mouse embryos

18 Sept 2015

Abstract excerpt

STUDY QUESTION: Does in vitro fertilization (IVF) induce comprehensive and consistent changes in gene expression associated with mitochondrial biogenesis and function in mouse embryos from the pre- to post-implantation stage? SUMMARY ANSWER: IVF-induced consistent mitochondrial dysfunction in early mouse embryos by altering the expression of a number of mitochondria-related genes. WHAT IS KNOWN ALREADY: Although...

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PMID: 26385791
DOI: 10.1093/humrep/dev228

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