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Proteomic and metabolomic insights into oxidative stress response activation in mouse embryos generated by in vitro fertilization

1 Jan 2025

Abstract excerpt

Abstract STUDY QUESTION How different is the global proteomic and metabolic profile of mouse blastocysts generated by IVF, cultured in optimal (5% O2) or stressful (20% O2) conditions, compared to in vivo generated blastocysts? SUMMARY ANSWER We found that in IVF-generated embryos: (i) the proteome was more sensitive to high oxygen levels than the global metabolomic profile; (ii) enzymes involved in splicing and...

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PMID: 40416391
DOI: 10.1093/hropen/hoaf022

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