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Article

Propranolol selectively inhibits cervical cancer cell growth by suppressing the cGMP/PKG pathway

15 Jan 2019

Abstract excerpt

AIM: To observe the effect of propranolol in cervical cancer and investigate the mechanism of the effect． METHODS AND RESULTS: We found 5 direct protein targets (DPTs) of propranolol (PRO) by DrugBank5.0 firstly. Next, we analyzed protein-protein interaction (PPI) network and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of PRO DPTs and the result showed that PRO was linked with cGMP/PKG pathway. Then,...

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PMID: 30841438
DOI: 10.1016/j.biopha.2019.01.027

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