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Article

Towards embedding Caco-2 model of gut interface in a microfluidic device to enable multi-organ models for systems biology

1 Mar 2019

Abstract excerpt

BACKGROUND: A cancer cell line originating from human epithelial colorectal adenocarcinoma (Caco-2 cells) serves as a high capacity model for a preclinical screening of drugs. Recent need for incorporating barrier tissue into multi-organ chips calls for inclusion of Caco-2 cells into microperfused environment. RESULTS: This article describes a series of systems biology insights obtained from comparing Caco-2...

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PMID: 30836980
DOI: 10.1186/s12918-019-0686-y

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