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Directed Differentiation of Human Pluripotent Stem Cells to Podocytes under Defined Conditions

26 Feb 2019

Abstract excerpt

A major cause of chronic kidney disease (CKD) is glomerular disease, which can be attributed to a spectrum of podocyte disorders. Podocytes are non-proliferative, terminally differentiated cells. Thus, the limited supply of primary podocytes impedes CKD research. Differentiation of human pluripotent stem cells (hPSCs) into podocytes has the potential to produce podocytes for disease modeling, drug screening, and...

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PMID: 30808965
DOI: 10.1038/s41598-019-39504-8

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