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Article

A cocrystal structure of dengue capsid protein in complex of inhibitor.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2020

Xia Hongjie, Xie Xuping, Zou Jing, Noble Christian G, Russell William K, Holthauzen Luis Marcelo F, Choi Kyung H, White Mark A, Shi Pei-Yong

Abstract excerpt

Dengue virus (DENV) was designated as a top 10 public health threat by the World Health Organization in 2019. No clinically approved anti-DENV drug is currently available. Here we report the high-resolution cocrystal structure (1.5 Å) of the DENV-2 capsid protein in complex with an inhibitor that potently suppresses DENV-2 but not other DENV serotypes. The inhibitor induces a "kissing" interaction between two...

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Identifiers

PMID: 32669438
DOI: 10.1073/pnas.2003056117
PMCID: PMC7395448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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