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Article

Disruption of Quorum Sensing and Virulence in Burkholderia cenocepacia by a Structural Analogue of the cis -2-Dodecenoic Acid Signal

14 Feb 2019

Abstract excerpt

Burkholderia cenocepacia is an important opportunistic pathogen which can cause life-threatening infections in susceptible individuals, particularly in cystic fibrosis and immunocompromised patients. It usually employs two types of quorum sensing (QS) systems, including the cis -2-dodecenoic acid (BDSF) system and N -acyl homoserine lactone (AHL) system, to regulate virulence. In this study, we have designed and...

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PMID: 30770405
DOI: 10.1128/aem.00105-19

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