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Article

H5N8 and H7N9 packaging signals constrain HA reassortment with a seasonal H3N2 influenza A virus

13 Feb 2019

Abstract excerpt

) necessitates a selective packaging mechanism to ensure incorporation of a complete set of segments into virus particles. Packaging signals serve as segment identifiers and enable segment-specific packaging. We have previously shown that packaging signals limit reassortment between heterologous IAV strains in a segment-dependent manner. Here, we evaluated the extent to which packaging signals prevent...

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PMID: 30760600
DOI: 10.1073/pnas.1818494116

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