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Article

Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of Sec63 in Collecting Ducts

11 Feb 2019

Abstract excerpt

Significance Statement CKD of various etiologies manifests with declining kidney function in the setting of progressive interstitial inflammation, with increased myofibroblasts and collagen deposition. In this study, the authors developed a novel genetic model, demonstrating that impairment of protein homeostatic mechanisms in the endoplasmic reticulum of collecting duct cells is sufficient to produce...

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Share to Biomedical Research and Pathophysiology
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PMID: 30745418
DOI: 10.1681/asn.2018060614

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