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Article

TRIM2, a novel member of the antiviral family, limits New World arenavirus entry

6 Feb 2019

Abstract excerpt

Tripartite motif (TRIM) proteins belong to a large family with many roles in host biology, including restricting virus infection. Here, we found that TRIM2, which has been implicated in cases of Charcot-Marie-Tooth disease (CMTD) in humans, acts by blocking hemorrhagic fever New World arenavirus (NWA) entry into cells. We show that Trim2-knockout mice, as well as primary fibroblasts from a CMTD patient with...

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PMID: 30726215
DOI: 10.1371/journal.pbio.3000137

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