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FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

5 Feb 2019

Abstract excerpt

Protective signaling from the leukemia microenvironment leads to leukemia cell persistence, development of resistance, and disease relapse. Here, we demonstrate that fibroblast growth factor 2 (FGF2) from bone marrow stromal cells is secreted in exosomes, which are subsequently endocytosed by leukemia cells, and protect leukemia cells from tyrosine kinase inhibitors (TKIs). Expression of FGF2 and its receptor,...

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PMID: 30720426
DOI: 10.7554/elife.40033

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