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Selective miRNA Expression Profile in Chronic Myeloid Leukemia K562 Cell-derived Exosomes

31 Dec 2013

Abstract excerpt

BACKGROUND: Chronic myeloid leukemia (CML) is a myeloproliferative disorder of hematopoietic stem cell scarrying the Philadelphia (Ph) chromosome and an oncogenic BCR-ABL1 fusion gene. The tyrosine kinase inhibitor (TKI) of BCR-ABL1 kinase is a treatment of choice for control of CML. OBJECTIVE: Recent studies have demonstrated that miRNAs within exosomes from cancer cells play crucial roles in initiation and...

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PMID: 24460325
DOI: 10.7314/apjcp.2013.14.12.7501

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