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Article

Genetic and metabolic predictors of hepatic fat content in a cohort of Italian children with obesity

23 Jan 2019

Abstract excerpt

To comprehensively explore metabolic and genetic contributors to liver fat accumulation in overweight/obese children. Two hundred thirty Italian children with obesity were investigated for metabolic parameters and genotyped for PNPLA3 , TM6SF2 , GCKR , and MBOAT7 gene variants. Percentage hepatic fat content (HFF%) was measured by nuclear magnetic resonance. HFF% was positively related with BMI, HOMA IR ,...

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PMID: 30710115
DOI: 10.1038/s41390-019-0303-1

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