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Article

AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma.

Cell death and differentiation - 1 Jul 2020

Das Ishani, Gad Helge, Bräutigam Lars, Pudelko Linda, Tuominen Rainer, Höiom Veronica, Almlöf Ingrid, Rajagopal Varshni, Hansson Johan, Helleday Thomas, Egyházi Brage Suzanne, Warpman Berglund Ulrika

Abstract excerpt

Cutaneous malignant melanoma (CMM) is the deadliest form of skin cancer and clinically challenging due to its propensity to develop therapy resistance. Reactive oxygen species (ROS) can induce DNA damage and play a significant role in CMM. MTH1 protein protects from ROS damage and is often overexpressed in different cancer types including CMM. Herein, we report that MTH1 inhibitor TH1579 induced ROS levels,...

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Identifiers

PMID: 31919461
DOI: 10.1038/s41418-019-0488-1
PMCID: PMC7308409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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