Article
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans.
Cancer epidemiology - 1 Apr 2020
Boekstegers Felix, Marcelain Katherine, Barahona Ponce Carol, Baez Benavides Pablo F, Müller Bettina, de Toro Gonzalo, Retamales Javier, Barajas Olga, Ahumada Monica, Morales Erik, Rojas Armando, Sanhueza Verónica, Loader Denisse, Rivera María Teresa, Gutiérrez Lorena, Bernal Giuliano, Ortega Alejandro, Montalvo Domingo, Portiño Sergio, Bertrán Maria Enriqueta, Gabler Fernando, Spencer Loreto, Olloquequi Jordi, González Silos Rosa, Fischer Christine, Scherer Dominique, Jenab Mazda, Aleksandrova Krasimira, Katzke Verena, Weiderpass Elisabete, Moradi Tahereh, Fischer Krista, Bossers Willem, Brenner Hermann, Hveem Kristian, Eklund Niina, Völker Uwe, Waldenberger Melanie, Fuentes Guajardo Macarena, Gonzalez-Jose Rolando, Bedoya Gabriel, Bortolini Maria C, Canizales Samuel, Gallo Carla, Ruiz Linares Andres, Rothhammer Francisco, Lorenzo Bermejo Justo
Abstract excerpt
BACKGROUND: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. METHODS: This...
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