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Article

KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis

25 Jan 2019

Abstract excerpt

KDM4/JMJD2 Jumonji C-containing histone lysine demethylases (KDM4A-D) constitute an important class of epigenetic modulators in the transcriptional activation of cellular processes and genome stability. Interleukin-8 (IL-8) is overexpressed in gastric cancer, but the mechanisms and particularly the role of the epigenetic regulation of IL-8, are unclear. Here, we report that KDM4B, but not KDM4A/4C, upregulated...

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Share to Cancer Immunotherapy and Biomarkers
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PMID: 30683841
DOI: 10.1038/s41419-019-1305-y

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