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Article

Temporal dynamics of adenovirus 5 gene expression in normal human cells

24 Jan 2019

Abstract excerpt

Adenovirus executes a finely tuned transcriptional program upon infection of a cell. To better understand the temporal dynamics of the viral transcriptional program we performed highly sensitive digital PCR on samples extracted from arrested human lung fibroblasts infected with human adenovirus 5 strain dl309. We show that the first transcript made from viral genomes is the virus associated non-coding RNA, in...

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PMID: 30677073
DOI: 10.1371/journal.pone.0211192

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