Article
Expression of the type I DNA topoisomerase gene in adenovirus-5 infected human cells.
Nucleic acids research - 25 Feb 1990
Romig H, Richter A
Abstract excerpt
The amount of topoisomerase I specific mRNA increases three- to fivefold during the early phase of infection of HeLa cells with adenovirus-5. The observed increase in specific mRNA is mainly due to an increased rate of transcription of the gene. In human 293 cells, which constitutively express the viral E1A and E1B genes, we determined an elevated level of topoisomerase I mRNA, comparable to the amount of mRNA...
Topics
- Adenoviruses, Human
- Cell Nucleus
- Cell Transformation, Viral
- DNA Topoisomerases, Type I
- Gene Expression
- Genes
- HeLa Cells
- Humans
- Kinetics
- Mutation
- RNA, Messenger
- RNA, Neoplasm