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Inhibiting the MCM8‐9 complex selectively sensitizes cancer cells to cisplatin and olaparib

16 Jan 2019

Abstract excerpt

MCM8 and MCM9 are paralogues of the MCM2-7 eukaryotic DNA replication helicase proteins and play a crucial role in a homologous recombination-mediated repair process to resolve replication stress by fork stalling. Thus, deficiency of MCM8-9 sensitizes cells to replication stress caused, for example, by platinum compounds that induce interstrand cross-links. It is suggested that cancer cells undergo more...

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PMID: 30648820
DOI: 10.1111/cas.13941

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