Article
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
Nature genetics - 1 Feb 2019
Kristjansson Ragnar P, Benonisdottir Stefania, Davidsson Olafur B, Oddsson Asmundur, Tragante Vinicius, Sigurdsson Jon K, Stefansdottir Lilja, Jonsson Stefan, Jensson Brynjar O, Arthur Joseph G, Arnadottir Gudny A, Sulem Gerald, Halldorsson Bjarni V, Gunnarsson Bjarni, Halldorsson Gisli H, Stefansson Olafur A, Oskarsson Gudjon R, Deaton Aimee M, Olafsson Isleifur, Eyjolfsson Gudmundur I, Sigurdardottir Olof, Onundarson Pall T, Gislason David, Gislason Thorarinn, Ludviksson Bjorn R, Ludviksdottir Dora, Olafsdottir Thorunn A, Rafnar Thorunn, Masson Gisli, Zink Florian, Bjornsdottir Gyda, Magnusson Olafur Th, Bjornsdottir Unnur S, Thorleifsson Gudmar, Norddahl Gudmundur L, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Jonsdottir Ingileif, Sulem Patrick, Stefansson Kari
Abstract excerpt
Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide association studies on NP and CRS in Iceland and the UK (using UK Biobank data) with 4,366 NP cases, 5,608 CRS cases, and >700,000 controls. We found 10 markers associated with NP and 2 with CRS. We also tested 210 markers reported to associate with eosinophil...
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