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Article

COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials.

Journal of the National Cancer Institute - 1 Jul 2019

Hall Kathryn T, Buring Julie E, Mukamal Kenneth J, Vinayaga Moorthy M, Wayne Peter M, Kaptchuk Ted J, Battinelli Elisabeth M, Ridker Paul M, Sesso Howard D, Weinstein Stephanie J, Albanes Demetrius, Cook Nancy R, Chasman Daniel I

Abstract excerpt

BACKGROUND: Vitamins are among the most frequently used supplements (48% of US adults). However, little is known about contributions of genetic variation to their efficacy and safety. Multiple pathways link catechol-O-methyltransferase (COMT) to the vitamin E supplement, alpha-tocopherol, and cancer. METHODS: Here we determined if COMT exerted pharmacogenetic effects on cancer prevention in two randomized trials...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30624689
DOI: 10.1093/jnci/djy204
PMCID: PMC6624170

Genes

COMT

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