Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.

doi:10.1016/j.ajhg.2008.12.019

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Article

Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.

American journal of human genetics - 1 Feb 2009

Ferrucci Luigi, Perry John R B, Matteini Amy, Perola Markus, Tanaka Toshiko, Silander Kaisa, Rice Neil, Melzer David, Murray Anna, Cluett Christie, Fried Linda P, Albanes Demetrius, Corsi Anna-Maria, Cherubini Antonio, Guralnik Jack, Bandinelli Stefania, Singleton Andrew, Virtamo Jarmo, Walston Jeremy, Semba Richard D, Frayling Timothy M

Abstract excerpt

Low plasma levels of carotenoids and tocopherols are associated with increased risk of chronic disease and disability. Because dietary intake of these lipid-soluble antioxidant vitamins is only poorly correlated with plasma levels, we hypothesized that circulating carotenoids (vitamin A-related compounds) and tocopherols (vitamin E-related compounds) are affected by common genetic variation. By conducting a...

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PMID: 19185284
DOI: 10.1016/j.ajhg.2008.12.019
PMCID: PMC2668002

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