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Article

Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations

8 Jan 2019

Abstract excerpt

Abstract A subset of patients with gastric cancer have mutations in genes that participate in or regulate Wnt signaling at the level of ligand (Wnt) receptor (Fzd) binding. Moreover, increased Fzd expression is associated with poor clinical outcome. Despite these findings, there are no in vivo studies investigating the potential of targeting Wnt receptors for treating gastric cancer, and the specific Wnt receptor...

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PMID: 30622113
DOI: 10.1158/0008-5472.can-18-2095

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