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The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA

26 Feb 2015

Abstract excerpt

BACKGROUND: Highly active antiretroviral therapy (HAART) has transformed HIV-1 infection from a deadly disease to a manageable chronic illness, albeit does not provide a cure. The recently developed genome editing system called CRISPR/Cas9 offers a new tool to inactivate the integrated latent HIV-1 DNA and may serve as a new avenue toward cure. FINDINGS: We tested 10 sites in HIV-1 DNA that can be targeted by...

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PMID: 25808449
DOI: 10.1186/s12977-015-0150-z

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