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Selection and Characterization of Anti-Dengue NS1 Single Domain Antibodies

21 Dec 2018

Abstract excerpt

Reliable detection and diagnosis of dengue virus (DENV) is important for both patient care and epidemiological control. Starting with a llama immunized with a mixture of recombinant nonstructural protein 1 (NS1) antigen from the four DENV serotypes, a phage display immune library of single domain antibodies was constructed and binders selected which exhibited specificity and affinity for DENV NS1. Each of these...

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PMID: 30591706
DOI: 10.1038/s41598-018-35923-1

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